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White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system. The white matter is white because of the fatty substance (myelin) that surrounds the nerve fibers (axons). This myelin is found in almost all long nerve fibers, and acts as an electrical insulation.
[3] [4] On CT scans, leukoaraiosis appears as hypodense periventricular white-matter lesions. [ 5 ] The term "leukoaraiosis" was coined in 1986 [ 6 ] [ 7 ] by Hachinski , Potter, and Merskey as a descriptive term for rarefaction ("araiosis") of the white matter, showing up as decreased density on CT and increased signal intensity on T2/FLAIR ...
Fractional anisotropy (FA) is a scalar value between zero and one that describes the degree of anisotropy of a diffusion process. A value of zero means that diffusion is isotropic, i.e. it is unrestricted (or equally restricted) in all directions.
The gray matter remains normal in all characteristics while the white matter changes texture, becoming soft and gelatinous. Rarefaction of the white matter is seen through light microscopy and the small number of axons and U-fibers that were affected can also be seen. Numerous small cavities in the white matter are also apparent.
In September 2021, two studies [30] found white matter alterations in parts of the visual cortex and outside the visual cortex in patients with visual snow syndrome. In November 2023, a study [31] revealed that glutamate and serotonin are involved in brain connectivity alterations in areas of the visual, salience, and limbic systems in VSS ...
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For example, deep white matter hyperintensities are 2.5 to 3 times more likely to occur in bipolar disorder and major depressive disorder than control subjects. [ 3 ] [ 4 ] WMH volume, calculated as a potential diagnostic measure, has been shown to correlate to certain cognitive factors. [ 5 ]