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  2. Transplant rejection - Wikipedia

    en.wikipedia.org/wiki/Transplant_rejection

    The mechanism for chronic rejection is yet to be fully understood, but it is known that prior acute rejection episodes are the main clinical predictor for the development of chronic rejection. [6] In particular, the incidence increases following severe or persistent acute rejection, whereas acute rejection episodes with return to function back ...

  3. Alloimmunity - Wikipedia

    en.wikipedia.org/wiki/Alloimmunity

    Chronic rejection is not yet fully understood, but it is known that it is associated with alloantibody and cytokine production. Endothelium of the blood vessels is being damaged, therefore the graft is not sufficiently supplied with blood and is replaced with fibrous tissue ( fibrosis ). [ 4 ]

  4. Immunologic constant of rejection - Wikipedia

    en.wikipedia.org/wiki/Immunologic_Constant_of...

    The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic conditions like cancer and infection, along a diverse set of physiological circumstances of tissue damage or organ failure, including autoimmune disease or allograft rejection. [1]

  5. Xenotransplantation - Wikipedia

    en.wikipedia.org/wiki/Xenotransplantation

    There are several types of rejection organ xenografts are faced with, these include hyperacute rejection, acute vascular rejection, cellular rejection, and chronic rejection. [citation needed] A rapid, violent, and hyperacute response comes as a result of antibodies present in the host organism. These antibodies are known as xenoreactive ...

  6. Major histocompatibility complex - Wikipedia

    en.wikipedia.org/wiki/Major_histocompatibility...

    Acute cellular rejection occurs when the recipient's T lymphocytes are activated by the donor tissue, causing damage via mechanisms such as direct cytotoxicity from CD8 cells. Acute humoral rejection and chronic disfunction occurs when the recipient's anti-HLA antibodies form directed at HLA molecules present on endothelial cells of the ...

  7. Liver transplantation - Wikipedia

    en.wikipedia.org/wiki/Liver_transplantation

    Acute rejection is mediated by T cells (versus B-cell-mediated hyperacute rejection). It involves direct cytotoxicity and cytokine mediated pathways. Acute rejection is the most common and the primary target of immunosuppressive agents. Acute rejection is usually seen within days or weeks of the transplant. Chronic rejection is the presence of ...

  8. Kidney transplantation - Wikipedia

    en.wikipedia.org/wiki/Kidney_transplantation

    Kidney transplant rejection can be classified as cellular rejection or antibody-mediated rejection. Antibody-mediated rejection can be classified as hyperacute, acute, or chronic, depending on how long after the transplant it occurs. If rejection is suspected, a kidney biopsy should be obtained. [5]

  9. Alloantigen recognition - Wikipedia

    en.wikipedia.org/wiki/Alloantigen_recognition

    Rejection mediated by T lymphocytes sensitized by direct allorecognition pathway is predominant in the short period after the transplantation, but usually subsides with depletion of passenger cells while indirect recognition contributes to continuing graft damage and plays role in chronic rejection.