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12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade. [3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II. [4]
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal.
BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9). ). These two protein signaling molecules and their BMPR2-mediated effects play an important role in follicle development in preparation for ovulatio
Russian Army BMP-2 infantry fighting vehicle in front of a unit of main battle tanks in August 2021, a half year prior to hostilities with Ukraine. This variant mounts a 30-millimeter A272 ...
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