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Cerebrospinal fluid (CSF) is a clear, colorless transcellular body fluid found within the meningeal tissue that surrounds the vertebrate brain and spinal cord, and in the ventricles of the brain. CSF is mostly produced by specialized ependymal cells in the choroid plexuses of the ventricles of the brain, and absorbed in the arachnoid granulations .
This allows the cerebrospinal fluid to flow directly to the basal cisterns, thereby bypassing any obstruction. A surgical procedure to make an entry hole to access any of the ventricles is called a ventriculostomy. This is done to drain accumulated cerebrospinal fluid either through a temporary catheter or a permanent shunt. [citation needed]
Both of these deformations disrupt the laminar flow of CSF through the ventricular system, causing the force by the aqueduct on its surroundings to be lower than the compressive force being applied to the aqueduct. This greater compressive force could effectively stop the flow of CSF if the aqueduct closes due to the force. [8]
The majority of the CSF is formed in the choroid plexus and flows through the brain along a distinct pathway: moving through the cerebral ventricular system, into the subarachnoid space surrounding the brain, then draining into the systemic blood column via arachnoid granulations of the dural sinuses or to peripheral lymphatics along cranial ...
The blood–cerebrospinal fluid barrier (BCSFB) is a fluid–brain barrier that is composed of a pair of membranes that separate blood from CSF at the capillary level and CSF from brain tissue. [14] The blood–CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. [ 14 ]
Aqueductal stenosis, a narrowing of the cerebral aqueduct, obstructs the flow of CSF and has been associated with non-communicating hydrocephalus. Such narrowing can be congenital, arise via tumor compression (e.g. pinealoblastoma), or through cyclical gliosis secondary to an initial partial obstruction. [5]
The median aperture (median aperture of fourth ventricle or foramen of Magendie) is an opening at the caudal portion of the roof of the fourth ventricle. [1] It allows the flow of cerebrospinal fluid (CSF) from the fourth ventricle into the cisterna magna. [2] [3] The other openings of the fourth ventricle are the lateral apertures - one on ...
The central canal (also known as spinal foramen or ependymal canal) is the cerebrospinal fluid-filled space that runs through the spinal cord. [1] The central canal lies below and is connected to the ventricular system of the brain, from which it receives cerebrospinal fluid, and shares the same ependymal lining. The central canal helps to ...