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  2. Signal peptide - Wikipedia

    en.wikipedia.org/wiki/Signal_peptide

    A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) [1] present at the N-terminus (or occasionally nonclassically at the C-terminus [2] or internally) of most newly synthesized proteins that are destined toward the ...

  3. N-terminus - Wikipedia

    en.wikipedia.org/wiki/N-terminus

    It often contains signal peptide sequences, "intracellular postal codes" that direct delivery of the protein to the proper organelle. The signal peptide is typically removed at the destination by a signal peptidase. The N-terminal amino acid of a protein is an important determinant of its half-life (likelihood of being degraded).

  4. List of protein subcellular localization prediction tools

    en.wikipedia.org/wiki/List_of_protein_sub...

    MetaLocGramN is a gateway to a number of primary prediction methods (various types: signal peptide, beta-barrel, transmembrane helices and subcellular localization predictors). In author's benchmark, MetaLocGramN performed better in comparison to other SCL predictive methods, since the average Matthews correlation coefficient reached 0.806 that ...

  5. Target peptide - Wikipedia

    en.wikipedia.org/wiki/Target_peptide

    The mitochondrial targeting signal also known as presequence is a 10-70 amino acid long peptide that directs a newly synthesized protein to the mitochondria. It is found at the N-terminus end consists of an alternating pattern of hydrophobic and positively charged amino acids to form what is called an amphipathic helix.

  6. Signal peptide peptidase - Wikipedia

    en.wikipedia.org/wiki/Signal_Peptide_Peptidase

    In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species.

  7. These are the 14 Best Peptide Serums, According to ... - AOL

    www.aol.com/lifestyle/16-best-peptide-serums...

    “Carrier peptides deliver trace minerals to boost collagen, while signal peptides signal different areas of the skin to promote elastin, collagen, and other proteins,” says Dr. Harold Lancer ...

  8. Protein function prediction - Wikipedia

    en.wikipedia.org/wiki/Protein_function_prediction

    Protein function is a broad term: the roles of proteins range from catalysis of biochemical reactions to transport to signal transduction, and a single protein may play a role in multiple processes or cellular pathways. [1] Generally, function can be thought of as, "anything that happens to or through a protein". [1]

  9. Topogenic sequence - Wikipedia

    en.wikipedia.org/wiki/Topogenic_sequence

    The position of the sequence may be at the end, e.g. N-terminal signal sequence, or in mid parts of the nascent protein, e.g. stop-transfer anchor sequences and signal-anchor sequences. [3] If the sequence is at the end of the polypeptide, it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase, and subsequently ...