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The dapivirine vaginal ring (DPV-VR) for women at substantial risk of HIV infection who do not have access to oral PrEP. [6] This article provides information regarding PrEP's medical uses, contraindications and side effects, societal and cultural perspectives on its usage, and recent research studies.
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. [1] There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy ...
Pre-exposure prophylaxis (PrEP), is the use of medications to prevent the spread of disease in people who have not yet been exposed to a disease-causing agent. Vaccination is the most commonly used form of pre-exposure prophylaxis; other forms of pre-exposure prophylaxis generally involve drug treatment, known as chemoprophylaxis.
Dolutegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication. [7] Dolutegravir was approved for medical use in the United States in 2013. [7] It is on the World Health Organization's List of Essential Medicines. [9]
A similar result was observed with the TDF2 trial, conducted by the United States Centers for Disease Control in partnership with the Botswana Ministry of Health. [99] The trial followed 1200 HIV negative men and women in Francistown, Botswana, a city known to have one of the world's highest HIV infection rates. [99]
Universal precautions are an infection control practice. Under universal precautions all patients were considered to be possible carriers of blood-borne pathogens. The guideline recommended wearing gloves when collecting or handling blood and body fluids contaminated with blood, wearing face shields when there was danger of blood splashing on mucous membranes ,and disposing of all needles and ...
For HIV infection that has not previously been treated, the United States Department of Health and Human Services Panel on Antiretroviral Guidelines recommends the use of efavirenz in combination with tenofovir/emtricitabine (Truvada) as one of the preferred NNRTI-based regimens in adults and adolescents [9] and children.
Elvitegravir (EVG) is an integrase inhibitor used to treat HIV infection. It was developed [ 1 ] by the pharmaceutical company Gilead Sciences , which licensed EVG from Japan Tobacco in March 2008. [ 2 ] [ 3 ] [ 4 ] The drug gained approval by the U.S. Food and Drug Administration on August 27, 2012, for use in adult patients starting HIV ...
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