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Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body.
Hox genes are found in bilateral animals, including Drosophila (in which they were first discovered) and humans. Hox genes are a subset of the homeobox genes. The Hox genes are often conserved across species, so some of the Hox genes of Drosophila are homologous to those in humans. In general, Hox genes play a role of regulating expression of ...
[18] [19] The regulation of Hox genes is highly complex and involves reciprocal interactions, mostly inhibitory. Drosophila is known to use the polycomb and trithorax complexes to maintain the expression of Hox genes after the down-regulation of the pair-rule and gap genes that occurs during larval development.
This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21.32 region. [6] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer ) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. [5] [6] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic ...
HOXA11-AS lncRNA is a long non-coding RNA from the antisense strand in the homeobox A (HOXA gene). The HOX gene contains four clusters (A, B, C, and D). The sense strand of the HOXA gene codes for proteins. Alternative names for HOXA11-AS lncRNA are: HOXA-AS5, HOXA11S, HOXA11-AS1, HOXA11AS, or NCRNA00076.
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
15413 Ensembl ENSG00000120075 ENSMUSG00000038700 UniProt P09067 P09079 RefSeq (mRNA) NM_002147 NM_008268 RefSeq (protein) NP_002138 NP_032294 Location (UCSC) Chr 17: 48.59 – 48.59 Mb Chr 11: 96.19 – 96.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene. Function This gene is a member of the Antp ...