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Carbon tetrachloride is a suspected human carcinogen but there is no sufficient evidence of carcinogenicity in humans. [23] The World Health Organization reports carbon tetrachloride can induce hepatocellular carcinomas (hepatomas) in mice and rats. The doses inducing hepatic tumors in mice and rats are higher than those inducing cell toxicity ...
Carbon tetrachloride is commonly used to induce acute type A liver injury in animal models. Idiosyncratic (type B) injury occurs without warning, when agents cause non-predictable hepatotoxicity in susceptible individuals, which is not related to dose and has a variable latency period. [8]
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
IARC group 2B substances, mixtures and exposure circumstances are those that have been classified as "possibly carcinogenic to humans" by the International Agency for Research on Cancer (IARC) as [1] This category is used when there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals.
Faraday was previously falsely credited for the synthesis of tetrachloroethylene, which in reality, was carbon tetrachloride. [non-primary source needed] While trying to make Faraday's "protochloride of carbon", Regnault found that his compound was different from Faraday's. Victor Regnault stated "According to Faraday, the chloride of carbon ...
In addition, a variety of simple chlorinated hydrocarbons including dichloromethane, chloroform, and carbon tetrachloride have been isolated from marine algae. [7] A majority of the chloromethane in the environment is produced naturally by biological decomposition, forest fires, and volcanoes.
Many gases have toxic properties, which are often assessed using the LC 50 (median lethal concentration) measure. In the United States, many of these gases have been assigned an NFPA 704 health rating of 4 (may be fatal) or 3 (may cause serious or permanent injury), and/or exposure limits (TLV, TWA/PEL, STEL, or REL) determined by the ACGIH professional association.
Hexachloroethane (perchloroethane) is an organochlorine compound with the chemical formula (CCl 3) 2.It is a white or colorless solid at room temperature with a camphor-like odor. [3]