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Carbon tetrachloride is a suspected human carcinogen but there is no sufficient evidence of carcinogenicity in humans. [23] The World Health Organization reports carbon tetrachloride can induce hepatocellular carcinomas (hepatomas) in mice and rats. The doses inducing hepatic tumors in mice and rats are higher than those inducing cell toxicity ...
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Carbon tetrachloride is commonly used to induce acute type A liver injury in animal models. Idiosyncratic (type B) injury occurs without warning, when agents cause non-predictable hepatotoxicity in susceptible individuals, which is not related to dose and has a variable latency period. [8]
Methylene chloride, after being metabolized, can cause carbon monoxide poisoning. [69] Carbon tetrachloride can cause significant damage to multiple systems, but its association with liver damage is so strong that it is used in animal models to induce liver injury. [70] Benzene use can cause bone marrow depression. [71] It is also a known ...
IARC group 2B substances, mixtures and exposure circumstances are those that have been classified as "possibly carcinogenic to humans" by the International Agency for Research on Cancer (IARC) as [1] This category is used when there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals.
In addition, a variety of simple chlorinated hydrocarbons including dichloromethane, chloroform, and carbon tetrachloride have been isolated from marine algae. [7] A majority of the chloromethane in the environment is produced naturally by biological decomposition, forest fires, and volcanoes.
Carbon disulphide, disulphur dichloride, benzene, including benzole, carbon tetrachloride and trichlorethylene: Processes in which these substances are used, or given off as vapour, in the manufacture of indiarubber or of articles or goods made wholly or partially of indiarubber Pitch
Carbon tetrachloride (CCl 4) can turn into phosgene when exposed to heat in air. This was a problem as carbon tetrachloride is an effective fire suppressant and was formerly in widespread use in fire extinguishers. [15] There are reports of fatalities caused by its use to fight fires in confined spaces. [16]