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Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. [6] It may be used together with other medications to treat pneumonia , and endocarditis . [ 6 ]
The following is a list of antibiotics.The highest division between antibiotics is bactericidal and bacteriostatic.Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
Cloxacillin is an antibiotic useful for the treatment of several bacterial infections. [1] This includes impetigo, cellulitis, pneumonia, septic arthritis, and otitis externa. [1]
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Ampicillin/flucloxacillin also known as co-fluampicil (), and sold under the tradename Magnapen, is a combination drug of the two β-lactam antibiotics, ampicillin and flucloxacillin, both in equal amounts, available in a capsule and as a liquid, both taken by mouth, and as a formulation which can be given by injection into muscle or vein.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Oxacillin is a penicillinase-resistant β-lactam.It is similar to methicillin, and has replaced methicillin in clinical use.Other related compounds are nafcillin, cloxacillin, dicloxacillin, and flucloxacillin.
Like all isoxazolyl penicillins, flucloxacillin is semisynthetic; it is "built around" 6-APA (the penicillin core), which is synthesized by P. chrysogenum. You may want to read this very interesting article (which someone should really work into beta-lactam antibiotic) and this 1970 paper, one of the first to report on flucloxacillin.