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[8] [50] Subclinical hypothyroidism is estimated to affect approximately 2% of children; in adults, subclinical hypothyroidism is more common in the elderly, and in White people. [49] There is a much higher rate of thyroid disorders, the most common of which is hypothyroidism, in individuals with Down syndrome [30] [62] and Turner syndrome. [30]
Cold sensitivity may be a symptom of hypothyroidism, anemia, low body weight, iron deficiency, vitamin B 12 deficiency, fevers, fibromyalgia or vasoconstriction. [2] There may also be differences in people in the expression of uncoupling proteins , thus affecting their amount of thermogenesis .
Thyroid disease also has a marked effect on BMR, since thyroid hormones regulate the rate of cellular metabolism. [3] Hyperthyroidism —in which there is an increase in the production of thyroid hormones—leads to a high BMR, while hypothyroidism —in which thyroid hormones are depleted—causes a low BMR.
Thyroid diseases are highly prevalent worldwide, [10] [11] [12] and treatment varies based on the disorder. Levothyroxine is the mainstay of treatment for people with hypothyroidism, [13] while people with hyperthyroidism caused by Graves' disease can be managed with iodine therapy, antithyroid medication, or surgical removal of the thyroid ...
Myxedema coma is an extreme or decompensated form of hypothyroidism and while uncommon, is potentially lethal. [1] [2] [3] A person may have laboratory values identical to a "normal" hypothyroid state, but a stressful event (such as an infection, myocardial infarction, or stroke) precipitates the myxedema coma state, usually in the elderly.
One small, older study conducted at the University of Groningen found that when couples wore socks during intimacy, about 80% of the couples achieved orgasm compared with 50% without socks.
Age can be a factor in a person's ability to adapt to temperature variations. Studies have shown that younger people adapt more efficiently to contact with cold surfaces than elderly people. Notably, a good level of fitness allowed the elderly people to cope better and offset somewhat the drop off to their ability to thermoregulate due to old age.
Thyroid hormones lead to heat generation in humans. However, the thyronamines function via some unknown mechanism to inhibit neuronal activity; this plays an important role in the hibernation cycles of mammals and the moulting behaviour of birds. One effect of administering the thyronamines is a severe drop in body temperature.
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