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  2. Deletion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Deletion_(genetics)

    In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is left out during DNA replication.

  3. Deletion mapping - Wikipedia

    en.wikipedia.org/wiki/Deletion_mapping

    In genetics and especially genetic engineering, deletion mapping is a technique used to find out the mutation sites within a gene. The principle of deletion mapping involves crossing a strain which has a point mutation in a gene, with multiple strains who each carry a deletion in a different region of the same gene.

  4. Cytogenetic notation - Wikipedia

    en.wikipedia.org/wiki/Cytogenetic_notation

    Deletion der: Derivative chromosome: dic: Dicentric chromosome: dim: diminished signal intensity dn: de novo (not inherited) chromosomal abnormality dup: Duplication of a portion of a chromosome enh: enhanced signal intensity fra: Fragile site (usually used with fragile X syndrome) h: Heterochromatic region of chromosome i: Isochromosome: idic

  5. Gene knockout - Wikipedia

    en.wikipedia.org/wiki/Gene_knockout

    Gene knockout by mutation is commonly carried out in bacteria. An early instance of the use of this technique in Escherichia coli was published in 1989 by Hamilton, et al. [2] In this experiment, two sequential recombinations were used to delete the gene.

  6. Chromosomal rearrangement - Wikipedia

    en.wikipedia.org/wiki/Chromosomal_rearrangement

    This theory is lacking in theoretical support because mutations that cause a large reduction in fitness can only be fixed through genetic drift in small, inbred populations, and the effects of chromosomal rearrangements on fitness are unpredictable and vary greatly in plant and animal species.

  7. Loss of heterozygosity - Wikipedia

    en.wikipedia.org/wiki/Loss_of_heterozygosity

    Second Hit: While the second hit is commonly assumed to be a deletion that results in loss of the remaining functioning TSG allele, the original published mechanism of RB1 LOH was mitotic recombination/gene conversion/copy-neutral LOH, not deletion. There is a critical difference between deletion and CN-LOH, as the latter mechanism cannot be ...

  8. Crick, Brenner et al. experiment - Wikipedia

    en.wikipedia.org/wiki/Crick,_Brenner_et_al...

    The Crick, Brenner et al. experiment (1961) was a scientific experiment performed by Francis Crick, Sydney Brenner, Leslie Barnett and R.J. Watts-Tobin. It was a key experiment in the development of what is now known as molecular biology and led to a publication entitled "The General Nature of the Genetic Code for Proteins" and according to the historian of Science Horace Judson is "regarded ...

  9. Indel - Wikipedia

    en.wikipedia.org/wiki/Indel

    Indel (insertion-deletion) is a molecular biology term for an insertion or deletion of bases in the genome of an organism. Indels ≥ 50 bases in length are classified as structural variants. [1] [2] In coding regions of the genome, unless the length of an indel is a multiple of 3, it will produce a frameshift mutation.