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Chemical structure of the folate family. Folate (vitamin B 9) refers to the many forms of folic acid and its related compounds, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid, folacin, and pteroylglutamic acid.
The un-methylated form, folic acid (vitamin B 9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase to become biologically active. [1] It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate.
Vitamin B 10: para-aminobenzoic acid (pABA or PABA), a chemical component of the folate molecule produced by plants and bacteria, and found in many foods. [40] [41] It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions. [40] [42]
And seaweed is a good source of folate, which is important for brain development from conception to old age. You can buy edible seaweed at the supermarket. ... And many brain chemicals, including ...
Tetrahydrofolic acid is a cofactor in many reactions, especially in the synthesis (or anabolism) of amino acids and nucleic acids.In addition, it serves as a carrier molecule for single-carbon moieties, that is, groups containing one carbon atom e.g. methyl, methylene, methenyl, formyl, or formimino.
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B 9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. [1] Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.
For folate-analogue drugs see antifolates. Pages in category "Folates" The following 15 pages are in this category, out of 15 total.
[6R]-5,10-methylene-THF is a biomodulator that has proven to enhance the desired cytotoxic antitumor effect of Fluorouracil (5-FU) and can bypass the metabolic pathway required by other folates (such as leucovorin) to achieve necessary activation. [4]
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