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They have been marketed as herbal incense, or "herbal smoking blends", [6] and sold under common names like K2, spice, [8] and synthetic marijuana. [5] They are often labeled "not for human consumption" for liability defense. [ 8 ]
More than half a dozen countries had banned herbal blends containing synthetic cannabinoids as of 2010 and many others were also considering banning them. [8] In the US, the states of Kansas, Georgia, Alabama, Tennessee, Missouri, Louisiana, Mississippi, Arkansas, and New York banned K2, herbal incense.
This synthetic chemical compound was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February and June 2009. [3] It was discovered by, and named after, John W. Huffman. [4] In the United States, JWH-398 is a Schedule I controlled substance. [5]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
It was also used for smoking cessation; Other notable synthetic cannabinoids include: JWH-018, a potent synthetic cannabinoid agonist discovered by John W. Huffman at Clemson University. It was often sold in legal smoke blends collectively known as "spice". Several countries and states have moved to ban it legally. JWH-073
Synthetic cannabinoids are known under a variety of names including K2, Spice, Black Mamba, Bombay Blue, Genie, Zohai, [38] Banana Cream Nuke, Krypton, and Lava Red. [39] They are often called "synthetic marijuana," "herbal incense," or "herbal smoking blends" and often labeled "not for human consumption."
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