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Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside . [1] [2] The term can also refer more generally to any organic molecule that contains amino sugar substructures.
Around 16% of amikacin crosses the placenta; while the half-life of amikacin in the mother is 2 hours, it is 3.7 hours in the fetus. [14] A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. While it is known to cross the placenta, amikacin is only partially secreted in ...
ATN presents with acute kidney injury (AKI) and is one of the most common causes of AKI. [2] Common causes of ATN include low blood pressure and use of nephrotoxic drugs. [2] The presence of "muddy brown casts" of epithelial cells found in the urine during urinalysis is pathognomonic for ATN. [3] Management relies on aggressive treatment of the ...
There can be vestibular dysfunction, such as some minor hearing loss after using the medication for 2 to 4 months. A certain block effect of neuromuscular. Can cause allergic reactions: rash, drug fever, facial flushing or pale, asthma, palpitations, sense of suppression in the chest, abdominal pain, anaphylactic shock.
Other nephrotoxic drugs (such as aminoglycosides): Increased risk of serious renal damage; Cytostatic drugs: Increased risk of kidney damage, hypotension, and bronchospasms; Transfusion of leukocytes: Risk of pulmonal (lung) damage occurs, space the intervals between the application of amphotericin B and the transfusion, and monitor pulmonary ...
The scarring of the small blood vessels, called capillary sclerosis, is the initial lesion of analgesic nephropathy. [7] Found in the renal pelvis, ureter, and capillaries supplying the nephrons, capillary sclerosis is thought to lead to renal papillary necrosis and, in turn, chronic interstitial nephritis.
Plazomicin, sold under the brand name Zemdri, is an aminoglycoside antibiotic used to treat complicated urinary tract infections. [2] As of 2019 it is recommended only for those in whom alternatives are not an option. [2] It is given by injection into a vein. [2] Common side effects include kidney problems, diarrhea, nausea, and blood pressure ...