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Differential diagnosis can be challenging due to the number of overlapping symptoms, shared between several motor neuron diseases. [14] Frequently, the diagnosis is based on clinical findings (i.e. LMN vs. UMN signs and symptoms, patterns of weakness), family history of MND, and a variation of tests, many of which are used to rule out disease ...
Public awareness of the disease gained prominence upon the diagnosis of baseball player Lou Gehrig, whose name would become an alternative title for the disease. Astrophysicist Stephen Hawking , whose ALS was diagnosed in 1963, had the disease for 55 years, the longest recorded time one had the disease.
Symptoms of upper motor neuron involvement include tight and stiff muscles and exaggerated reflexes (hyperreflexia), including an overactive gag reflex. [23] While the disease does not cause pain directly, pain is a symptom experienced by most people with ALS caused by reduced mobility. [35]
Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for amyotrophic lateral sclerosis (ALS) because of the similarity in the clinical picture, especially if muscle fasciculations are present.
Conversely, a lower motor neuron lesion affects nerve fibers traveling from the anterior horn of the spinal cord or the cranial motor nuclei to the relevant muscle(s). [ 1 ] Upper motor neuron lesions occur in the brain or the spinal cord as the result of stroke , multiple sclerosis , traumatic brain injury , cerebral palsy , atypical ...
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In cases where being classified as being PMA rather than ALS is likely to restrict access to services, it may be preferable to be diagnosed as "slowly progressive ALS" or "lower motor neuron predominant" ALS. An initial diagnosis of PMA could turn out to be slowly progressive ALS many years later, sometimes even decades after the initial ...
Rob Burrow's first heartbreaking words to his wife Lindsey after his motor neurone disease (MND) diagnosis have been revealed. Apprearing on Monday's episode of Loose Women on 6 November, Lindsey ...
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