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  2. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase [9] and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase ...

  3. DNA polymerase - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase

    A DNA polymerase is a member of a family of enzymes that ... with the sequence 5'-TTAGGG-3' recruits telomerase. Telomerase acts like other DNA polymerases by ...

  4. Telomerase reverse transcriptase - Wikipedia

    en.wikipedia.org/wiki/Telomerase_reverse...

    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component that serves as a template for the telomere repeat.

  5. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    Telomerase is a specialized DNA polymerase that consists of multiple protein subunits and an RNA component. The RNA component of telomerase anneals to the single ...

  6. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    During DNA replication, DNA polymerase cannot replicate the sequences present at the 3' ends of the parent strands. This is a consequence of its unidirectional mode of DNA synthesis: it can only attach new nucleotides to an existing 3'-end (that is, synthesis progresses 5'-3') and thus it requires a primer to initiate replication.

  7. Polymerase - Wikipedia

    en.wikipedia.org/wiki/Polymerase

    Structure of Taq DNA polymerase. In biochemistry, a polymerase is an enzyme (EC 2.7.7.6/7/19/48/49) that synthesizes long chains of polymers or nucleic acids. DNA polymerase and RNA polymerase are used to assemble DNA and RNA molecules, respectively, by copying a DNA template strand using base-pairing interactions or RNA by half ladder replication.

  8. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    The two major protein complexes that bind to telomeric DNA in S. cerevisiae are: [citation needed] the Cdc13-Stn1-Ten1 (CST) complex, which binds the single-stranded DNA (ssDNA) of the 3' G-rich overhang at the end of the telomere, and; the Rif1-Rif2-Rap1 complex, which binds the double-stranded DNA (dsDNA) preceding the 3' overhang.

  9. DNA - Wikipedia

    en.wikipedia.org/wiki/DNA

    Another DNA polymerase binds to the lagging strand. ... Telomerase is an unusual polymerase because it contains its own RNA template as part of its structure.