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Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by progressive blockage of the small veins in the lungs. [2] The blockage leads to high blood pressures in the arteries of the lungs, which, in turn, leads to heart failure .
In terms of complications, one of the most serious occurs when the superficial blood clot is associated with a deep vein thrombosis; this can then dislodge, traveling through the heart and occluding the dense capillary network of the lungs This is a pulmonary embolism which can be life-threatening. [5]
If the impaired vein function causes significant symptoms, such as swelling and ulcer formation, it is referred to as chronic venous disease. [3] It is sometimes called chronic peripheral venous insufficiency and should not be confused with post-thrombotic syndrome in which the deep veins have been damaged by previous deep vein thrombosis .
There are two major types of VTE: deep-vein thrombosis (DVT) and pulmonary embolism. [10] DVT is often found in the calf, accompanies with the swelling of limbs along the deep vein while pulmonary embolism causes chronic pulmonary hypertension. [11] VTE is the third deadliest cardiovascular disease in the world. [11]
Pulmonary vein stenosis can be congenital or acquired. [6]A rare abnormality that accounts for 0.4% of congenital heart diseases, congenital pulmonary vein stenosis results from the common right or left pulmonary vein failing to integrate into the left atrium (LA) during the vessel's embryonic development, obliterating the pulmonary veins partially or completely on one or both sides.
The inflammation surrounding the vein and compression of the vein may lead to blood clot formation. Pieces of the potentially infected clot can break off and travel through the right heart into the lungs as emboli, blocking branches of the pulmonary artery that carry deoxygenated blood from the right side of the heart to the lungs. [citation ...
It is an autoimmune disease and a form of vasculitis that affects small- and medium-size vessels in many organs but most commonly affects the upper respiratory tract, lungs and kidneys. [6] The signs and symptoms of GPA are highly varied and reflect which organs are supplied by the affected blood vessels.
Pulmonary vascular diseases are conditions that affect the pulmonary circulation. Examples are: [ 18 ] [ citation needed ] Pulmonary embolism , a blood clot that forms in a vein, breaks free, travels through the heart and lodges in the lungs (thromboembolism).