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InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them. [3] [4] The contents of InterPro consist of diagnostic signatures and the proteins that they significantly match.
In molecular biology, the protein domain SRCR is short for Scavenger receptor cysteine-rich domain. They are found solely in eukaryotes.These domains are present on the cell membrane and have a role in binding to specific ligands and are often found to be involved with the immune system.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
A spreadsheet consists of a table of cells arranged into rows and columns and referred to by the X and Y locations. X locations, the columns, are normally represented by letters, "A," "B," "C," etc., while rows are normally represented by numbers, 1, 2, 3, etc. A single cell can be referred to by addressing its row and column, "C10".
The WW domain is known to mediate regulatory protein complexes in various signaling networks, including the Hippo signaling pathway. [15] The importance of WW domain-mediated complexes in signaling was underscored by the characterization of genetic syndromes that are caused by loss-of-function point mutations in the WW domain or its cognate ligand.
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif in the extracellular portion adjacent to the cell membrane.
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Example of an approximately 40,000 probe spotted oligo microarray with enlarged inset to show detail. Microarray analysis techniques are used in interpreting the data generated from experiments on DNA (Gene chip analysis), RNA, and protein microarrays, which allow researchers to investigate the expression state of a large number of genes – in many cases, an organism's entire genome – in a ...
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