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The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors (KRAB zinc finger proteins). [1]
InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them.
Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell–cell recognition, cell-surface receptors, muscle structure and the immune system. [4]
A logical spreadsheet is a spreadsheet in which formulas take the form of logical constraints rather than function definitions.. In traditional spreadsheet systems, such as Excel, cells are partitioned into "directly specified" cells and "computed" cells and the formulas used to specify the values of computed cells are "functional", i.e. for every combination of values of the directly ...
Domains of unknown function (DUFs) represent a growing fraction of the Pfam database. The families are so named because they have been found to be conserved across species, but perform an unknown role. Each newly added DUF is named in order of addition. Names of these entries are updated as their functions are identified.
A cell on a different sheet of the same spreadsheet is usually addressed as: =SHEET2!A1 (that is; the first cell in sheet 2 of the same spreadsheet). Some spreadsheet implementations in Excel allow cell references to another spreadsheet (not the currently open and active file) on the same computer or a local network.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, [2] and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune ...