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Common side effects of valproate include nausea, vomiting, somnolence, and dry mouth. [7] Serious side effects can include liver failure, and regular monitoring of liver function tests is therefore recommended. [7] Other serious risks include pancreatitis and an increased suicide risk. [7]
Liver failure; Pancreatitis (these two usually occur in first 6 months and can be fatal); Leukopenia (low white blood cell count); Neutropenia (low neutrophil count); Pure red cell aplasia
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight gain you’ve ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 or 0.8–1.2 mEq/L (or millimolar). Signs and symptoms of toxicity include nausea, vomiting, diarrhea, and ataxia. [3] The most common side effects are lethargy and weight gain.
The prime example of this is valproic acid, marketed as a drug under the trade names Depakene, Depakote, and Divalproex. As of 2008, HDIs were being studied as a mitigator for neurodegenerative diseases such as Alzheimer's disease and Huntington's disease . [ 18 ]
Both newer and older drugs are generally equally effective in new onset epilepsy. [42] The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42]