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  2. HER2 - Wikipedia

    en.wikipedia.org/wiki/HER2

    It has been found that patients with ER+ (Estrogen receptor positive)/HER2+ compared with ER-/HER2+ breast cancers may actually benefit more from drugs that inhibit the PI3K/AKT molecular pathway. [37] Over-expression of HER2 can also be suppressed by the amplification of other genes.

  3. Hormone receptor positive breast tumor - Wikipedia

    en.wikipedia.org/wiki/Hormone_receptor_positive...

    ER-positive is one of the Receptor statuses identified in the classification of breast cancer.Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches look at these together, along with the tumor grade, to categorize breast cancer into several conceptual molecular classes [1] that have different prognoses [2] and may have ...

  4. Breast cancer classification - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer_classification

    Cells with or without these receptors are called ER positive (ER+), ER negative (ER-), PR positive (PR+), PR negative (PR-), HER2 positive (HER2+), and HER2 negative (HER2-). Cells with none of these receptors are called basal-like or triple negative. HER2-low has some HER2 proteins on the cell surface, but not enough to be classified as HER2 ...

  5. What is stage I triple-positive breast cancer? - AOL

    www.aol.com/lifestyle/office-star-jenna-fischer...

    When a tumor is “triple positive,” that means that its growth is fueled by both estrogen and progesterone hormones, as well as a protein called human epidermal growth factor receptor 2 (HER2).

  6. Trastuzumab - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab

    Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [31] [28] [32] [33] It is specifically used for cancer that is HER2 receptor positive. [31]

  7. Merck-AstraZeneca breast cancer drug reduces risk of ... - AOL

    www.aol.com/finance/merck-astrazeneca-breast...

    HER2-negative refers to cancer cells whose surfaces lack a protein called human epidermal growth factor receptor 2. Such cells tend to grow more slowly than HER2-positive ones, according to the ...

  8. Invasive carcinoma of no special type - Wikipedia

    en.wikipedia.org/wiki/Invasive_carcinoma_of_no...

    Selective estrogen receptor modifying drugs (e.g., tamoxifen) or aromatase inhibitors (e.g., anastrozole) may be offered to those with estrogen or progesterone receptor positive tumors. HER2-positive tumors may be treated with the targeted medical therapy (e.g., trastuzumab).

  9. Endocrine therapy resistance in breast cancer - Wikipedia

    en.wikipedia.org/wiki/Endocrine_therapy...

    Luminal B (ER and/or PR positive; HER2 positive) HER2-enriched (ER/PR negative; HER2 positive) Basal like (triple negative). [6] Additionally, cancers can be ER-/PR+ or ER+/PR-, but these are unnamed and relatively rare. [7] The receptor status of a cancer is assessed for all breast cancers as it has important implications on prognosis of the ...

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