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  2. Metoprolol - Wikipedia

    en.wikipedia.org/wiki/Metoprolol

    Metoprolol is classified as a moderately lipophilic beta blocker. [37] More lipophilic beta blockers tend to cross the blood–brain barrier more readily, with greater potential for effects in the central nervous system as well as associated neuropsychiatric side effects. [37] Metoprolol binds mainly to human serum albumin with an unbound ...

  3. Prevention of migraine attacks - Wikipedia

    en.wikipedia.org/wiki/Prevention_of_migraine_attacks

    The beta-blocker propranalol's effectiveness in headache treatment was a chance finding in patients receiving the drug for angina (chest pain due to a lack of blood to the heart muscle). The beta-blockers that are used in migraine treatment are propranolol, nadolol, timolol, metoprolol, and atenolol.

  4. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).

  5. Mechanism of action of aspirin - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

    Newer NSAID drugs called COX-2 selective inhibitors have been developed that inhibit only COX-2, with the hope for reduction of gastrointestinal side-effects. [8] However, several COX-2 selective inhibitors have subsequently been withdrawn after evidence emerged that COX-2 inhibitors increase the risk of heart attack. [ 9 ]

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  7. H2 receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/H2_receptor_antagonist

    Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.

  8. A 20-year-old amateur golfer just won a PGA Tour event. But ...

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    Nick Dunlap, a 20-year-old sophomore who plays golf for the University of Alabama, won the American Express tournament Sunday at the PGA West golf course in La Quinta, California.

  9. Move Over 'Rage Applying' And 'Quiet Quitting,' 2025 Will Be ...

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    Then there was “quiet quitting,” in which people chose to work as little as possible while still staying employed and probably applying for other positions. As 2025 approaches, a new trend ...

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