Search results
Results from the WOW.Com Content Network
Older dogs, similar to this 10-year-old Neapolitan Mastiff, often grow grey hairs on their muzzles, and some dogs grow grey hair all over. Not all dogs gain grey hair when aging. Aging in dogs varies from breed to breed, and affects the dog's health and physical ability. As with humans, advanced years often bring changes in a dog's ability to ...
In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. [9] Telomerase can be reactivated and telomeres restored to the embryonic state by somatic cell nuclear transfer. [18]
If a drug can inhibit telomerase in cancer cells, the telomeres of successive generations will progressively shorten, limiting tumor growth. [56] Telomerase is a good biomarker for cancer detection because most human cancer cells express high levels of it. Telomerase activity can be identified by its catalytic protein domain .
Maximum life span correlates negatively with antioxidant enzyme levels and free-radicals production and positively with rate of DNA repair [73] Female mammals express more Mn−SOD and glutathione peroxidase antioxidant enzymes than males. This has been hypothesized as the reason they live longer. [74]
Two concerns with applying telomerase inhibitors in cancer treatment are that effective treatment requires continuous, long-term drug application and that off-target effects are common. [30] For example, the telomerase inhibitor imetelstat, first proposed in 2003, [31] [32] has been held up in clinical trials due to hematological toxicity. [30]
Arthritis: When senior dogs develop changes in their vertebral bones, their spine can be pressed upon, and they can display the type of changes in the back legs that you describe.
However, other studies have shown that under certain conditions TERRA can recruit telomerase to telomeres. [2] TERRAs are essential for telomere length and maintenance. [3] [2] At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the CST Complex. [4]
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component that serves as a template for the telomere repeat.