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2. Treatment-resistant depression - Wikipedia

   en.wikipedia.org/wiki/Treatment-resistant_depression

   Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]

3. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

4. List of antidepressants - Wikipedia

   en.wikipedia.org/wiki/List_of_antidepressants

   This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.

5. Serotonin–norepinephrine–dopamine reuptake inhibitor

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   In addition, the augmentation of a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor with lisdexamfetamine, a norepinephrine–dopamine releasing agent, recently failed to separate from placebo in phase III clinical trials of individuals with treatment-resistant depression, and clinical development was ...

6. Tricyclic antidepressant - Wikipedia

   en.wikipedia.org/wiki/Tricyclic_antidepressant

   The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...

7. Transcranial direct-current stimulation - Wikipedia

   en.wikipedia.org/wiki/Transcranial_direct...

   A systematic review of placebo-controlled trials investigating tDCS treatment for major depressive disorder was published 2020. [11] The meta-analysis collated results across nine eligible studies (572 participants) up until December 2018 to estimate odds ratio (OR) and number needed to treat (NNT) of response and remission, and depression ...