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Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma , chondrosarcoma , and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [ 1 ]
Other bone modifying agents like zoledronic acid and denosumab can reduce prostate cancer bone pain, even though they have little effect on tumor size. [69] Metastases compress the spinal cord in up to 12% of those with metastatic prostate cancer causing pain, weakness, numbness, and paralysis.
It is well established that human PCa bone metastasis form osteoblastic lesions rather than osteolytic lesions seen in other cancers like breast cancer. [4] [5] Similarly, PC-3 and DU145 cells form osteolytic tumors. To develop an AI-PCa cell model that more closely mimics clinical disease, LNCaP sublines have been generated to provide the most ...
A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). [1] [4] Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. [1] There may be a lump, pain, or neurological signs from pressure. [1]
The PC3 cell line was established in 1979 from bone metastasis of grade IV of prostate cancer in a 62-year-old Caucasian male. [3] These cells do not respond to androgens, glucocorticoids or fibroblast growth factors, [4] but results suggest that the cells are influenced by epidermal growth factors. [5]
In advanced stages of prostate cancer, radiation is used to treat painful bone metastases or reduce spinal cord compression. Radiation therapy is also used after radical prostatectomy either for cancer recurrence or if multiple risk factors are found during surgery.
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