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Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. [1] It is one of three major endogenous estrogens, the others ...
Estrone is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [5] It is a relatively weak estrogen, with much lower activity than estradiol. [5] However, estrone is converted in the body into estradiol, which provides most or all of its ...
During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [14]
Esters of estrone and estriol also exist and are or have been used in clinical medicine, for example estrone sulfate (e.g., as estropipate), estriol succinate, and estriol glucuronide (as Emmenin and Progynon). [1] Ethinylestradiol is a more potent synthetic analogue of estradiol that is used widely in hormonal contraceptives. [1]
This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead. Estradiol derivatives
Estrone sulfate (E1S) is an estrogen medication and naturally occurring steroid hormone. [1] It is used in menopausal hormone therapy among other indications. [ 1 ] [ 2 ] As the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest).
This is an accepted version of this page This is the latest accepted revision, reviewed on 25 November 2024. Polycyclic organic compound having sterane as a core structure This article is about the family of polycyclic compounds. For the drugs, also used as performance-enhancing substances, see Anabolic steroid. For the scientific journal, see Steroids (journal). For the Death Grips EP, see ...
An estrogen ester is an ester of an estrogen, most typically of estradiol but also of other estrogens such as estrone, estriol, and even nonsteroidal estrogens like diethylstilbestrol. [ 1 ] [ 2 ] [ 3 ] Esterification renders estradiol into a prodrug of estradiol with increased resistance to first-pass metabolism , slightly improving its oral ...