Search results
Results from the WOW.Com Content Network
Silencers in eukaryotes control gene expression on a transcriptional level in which the mRNA is not transcribed. These DNA sequences may act as either silencers or enhancers based on the transcription factor that binds to the sequence and binding of this sequence will prevent promoters such as the TATA box from binding to RNA polymerase. [7]
Silencers are antagonists of enhancers that, when bound to its proper transcription factors called repressors, repress the transcription of the gene. Silencers and enhancers may be in close proximity to each other or may even be in the same region only differentiated by the transcription factor the region binds to.
These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [37] Among this constellation of sequences, enhancers and their associated transcription factor proteins have a leading role in the regulation of gene expression. [38] Enhancers are sequences of the genome that are major gene-regulatory elements.
These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [4] Among this constellation of sequences, enhancers and their associated transcription factor proteins have a leading role in the regulation of gene expression. [5] Enhancers are sequences of the genome that are major gene-regulatory elements.
However, this definition has changed to define cis-regulatory modules as a DNA sequence with transcription factor binding sites which are clustered into modular structures, including -but not limited to- locus control regions, promoters, enhancers, silencers, boundary control elements and other modulators. [4]
Transcription initiation is regulated by cis-acting elements (enhancers, silencers, isolators) within the regulatory regions of the DNA, and sequence-specific trans-acting factors that act as activators or repressors. [1] Gene transcription can also be regulated post-initiation by targeting the movement of the elongating polymerase. [40]
[9] [10] Genes may be regulated by multiple enhancer and silencer sequences that further modify the activity of promoters by binding activator or repressor proteins. [11] [12] Enhancers and silencers may be distantly located from the gene, many thousands of base pairs away. The binding of different transcription factors, therefore, regulates ...
Silencers are DNA sequences found in the 5′ flanking region of eukaryotic genes, assisting in the silencing of a gene. They can be found upstream, downstream, or within the gene of interest. [3] When repressors bind silencers, they act in a similar fashion as enhancers and bend over to prevent the interaction of RNA polymerase with promoters ...