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Bexarotene, sold under the brand Targretin, is an antineoplastic (anti-cancer) agent used for the treatment of cutaneous T cell lymphoma (CTCL). [4] It is a third-generation retinoid. [5] It was approved by the U.S. Food and Drug Administration (FDA) in December 1999, and the European Medicines Agency (EMA) in March 2001.
The majority of drugs used in cancer chemotherapy are cytostatic, many via cytotoxicity. A fundamental philosophy of medical oncology , including combination chemotherapy, is that different drugs work through different mechanisms, and that the results of using multiple drugs will be synergistic to some extent.
Astaxanthin / æ s t ə ˈ z æ n θ ɪ n / is a keto-carotenoid within a group of chemical compounds known as carotenoids or terpenes. [3] [4] [5] Astaxanthin is a metabolite of zeaxanthin and canthaxanthin, containing both hydroxyl and ketone functional groups.
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
5-ARIs are clinically used in the treatment of conditions that are exacerbated by DHT: [3] Mild-to-moderate benign prostatic hyperplasia and lower urinary tract symptoms; Pattern hair loss in both men and women; 5-ARIs can be used in the treatment of hirsutism in women. [1] The usefulness of 5-ARIs for the potential treatment of acne is uncertain.
Synthetic retinoids are utilized in cosmetic formulations, clinical dermatology, and the treatment of some forms of cancer. [ 1 ] Retinoids have many important functions throughout the body, including in vision, [ 2 ] regulation of skin proliferation and differentiation, growth of bone tissue, immune function, [ 3 ] and male fertility.
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
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