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The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
When TNF binds to its receptors, tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2), a pathway of signals is triggered within the target cell, resulting in an inflammatory response. sTNF can only activate TNFR1, whereas tmTNF can activate both TNFR1 and TNFR2, [6] as well as trigger inflammatory signaling ...
Protein (member #) Synonyms Gene Ligand(s) 1: Tumor necrosis factor receptor 1 (1A) CD120a TNFRSF1A: TNF (cachectin) Tumor necrosis factor receptor 2 (1B) CD120b TNFRSF1B: 3 Lymphotoxin beta receptor (3) CD18 LTBR: Lymphotoxin beta (TNF-C) 4 OX40 (4) CD134 TNFRSF4: OX40L: 5 CD40 (5) Bp50 CD40: CD154: 6 Fas receptor (6) Apo-1, CD95 FAS: FasL ...
27279 Ensembl ENSG00000006327 ENSMUSG00000023905 UniProt Q9NP84 Q9CR75 RefSeq (mRNA) NM_016639 NM_001161746 NM_013749 RefSeq (protein) NP_057723 NP_001155218 NP_038777 Location (UCSC) Chr 16: 3.02 – 3.02 Mb Chr 17: 23.89 – 23.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a ...
Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene. TNFRSF13B is a transmembrane protein of the TNF receptor superfamily found predominantly on the surface of B cells , which are an important part of the ...
Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body. [1]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/ TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
7133 21938 Ensembl ENSG00000028137 ENSMUSG00000028599 UniProt P20333 P25119 RefSeq (mRNA) NM_001066 NM_011610 RefSeq (protein) NP_001057 NP_035740 Location (UCSC) Chr 1: 12.17 – 12.21 Mb Chr 4: 144.94 – 144.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ...