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The WI-38 cell line stemmed from earlier work by Hayflick growing human cell cultures. [2]In the early 1960s, Hayflick and his colleague Paul Moorhead at the Wistar Institute in Philadelphia, Pennsylvania discovered that when normal human cells were stored in a freezer, the cells remembered the doubling level at which they were stored and, when reconstituted, began to divide from that level to ...
Hayflick produced the first oral polio vaccine ever made on his normal human cell strain WI-38. WI-38 is now used for the production of all of the Rubella Virus vaccine used in the Western Hemisphere. WI-38, or new diploid cell strains, are used today for the manufacture of most human virus vaccines produced throughout the world including those ...
The WI-38 cell strain he developed at the Institute with Paul S. Moorhead, Ph.D., became the substrate for the production of many human virus vaccines. [ 25 ] Helen Dean King , Ph.D.: a biologist and the first woman research professor at Wistar and one of the first in the U.S. [ 26 ] A faculty member from 1909 to 1950, Dr. King researched the ...
[11] [13] [14] Descendants of the fibroblast cells from these fetuses have been growing in labs ever since, as the WI-38 and MRC-5 cell lines. They are still used to grow vaccine viruses today. [15] [1] As of March 2017, billions of vaccines have been given that were made using the WI-38 line alone. [16]
To produce viral vaccines, candidate vaccine viruses are grown in mammalian, avian or insect tissue culture of cells with a finite lifespan. [5] These cells are typically Madin-Darby Canine Kidney cells, [6] but others are also used including monkey cell lines pMK and Vero and human cell lines HEK 293, MRC 5, Per.C6, PMK, and WI-38. [7]
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MRC-5 (Medical Research Council cell strain 5) is a diploid cell culture line composed of fibroblasts, originally developed from the lung tissue of a 14-week-old aborted white male fetus. [ 1 ] [ 2 ] The cell line was isolated by J.P. Jacobs and colleagues in September 1966 from the seventh population doubling of the original strain, and MRC-5 ...
Pages in category "Human cell lines" ... WI-38; Z. ZR-75-1 This page was last edited on 23 November 2019, at 17:55 (UTC). Text is available under the ...