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The efficacy of solifenacin to treat neurogenic detrusor overactivity (NDO) was established in two clinical trials with a total of 95 pediatric NDO participants, ages two to 17 years old. [2] The studies were designed to measure (as a primary efficacy endpoint) the maximum amount of urine the bladder could hold after 24 weeks of treatment. [2]
[13] [4] [2] [1] It works equally well to antimuscarinic medication such as solifenacin or tolterodine. [6] [3] In the United Kingdom it is less preferred to these agents. [7] Mirabegron is also indicated to treat neurogenic detrusor overactivity (NDO), a bladder dysfunction related to neurological impairment, in children ages three years and ...
The CDC recommends three flu vaccines for people 65 and older: the Fluzone High-Dose inactivated flu ... is most effective in the first year and wanes over 10 years. ... and pregnant women.
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
The CDC’s new COVID-19 vaccine recommendations suggest a second dose of the updated COVID-19 vaccine for people who are 65+, as well as those who are moderately or severely immunocompromised ...
Last year, the committee only recommended an optional additional dose for the age group. "Most COVID-19 deaths and hospitalizations last year were among people 65 years and older.
If there is no guidance then pick the mid point between the dose range extremes. The DDD of a drug is reviewed after three years. Ad hoc requests for change may be made but are discouraged and generally not permitted unless the main indication for the drug has changed or the average dose used has changed by more than 50%. [3]
Each year, RSV infections cause about 177,000 hospitalizations and 14,000 deaths in adults aged 65 and older, per CDC data. It also leads to about 58,000 hospitalizations and 500 deaths in ...