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Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, [5]: 6822 [6] is a zymogen, that is, an inactive enzyme. The activated form plays an important role in regulating anticoagulation , inflammation , and cell death and maintaining the permeability of blood vessel walls in humans and other animals.
Activated protein C–protein C inhibitor ( APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). [ 1][ 2][ 3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications. [ 2][ 3][ 4] It is a marker of thrombin generation and indicates hypercoagulability ...
Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. It acts as an enzyme to convert plasminogen into its active form plasmin, the major enzyme responsible for clot breakdown. It is a serine protease (EC 3.4.21.68) found on endothelial cells lining the blood vessels.
Kringle domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages. These are important in protein –protein interactions with blood coagulation factors. Their name refers to the Kringle, a Scandinavian pastry which they somewhat resemble. Kringle domains have been found in plasminogen, hepatocyte ...
DNA and RNA codon tables. A codon table can be used to translate a genetic code into a sequence of amino acids. [1][2] The standard genetic code is traditionally represented as an RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis. [2][3] The mRNA sequence is ...
InterPro. High-molecular-weight kininogen (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the kallikrein-kinin system. HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby ...
Tissue factor. Tissue factor, also called platelet tissue factor or Coagulation factor III, [5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene. Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin.
Blood plasma fractionation. Blood plasma fractionation are the general processes separating the various components of blood plasma, which in turn is a component of blood obtained through blood fractionation. Plasma-derived immunoglobulins are giving a new narrative to healthcare across a wide range of autoimmune inflammatory diseases.
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