Ad
related to: zdv reverse transcriptaseapexbt.com has been visited by 10K+ users in the past month
Search results
Results from the WOW.Com Content Network
ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. [6] It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. [6] Zidovudine was first described in 1964. [7] It was resynthesized from a public-domain formula by Burroughs Wellcome. [8]
Zidovudine (ZDV) (also known as AZT and sold as Retrovir) is an antiretroviral drug used in the prevention and treatment of HIV/AIDS. Classed as a nucleoside analogue reverse-transcriptase inhibitor, it inhibits HIV's reverse transcriptase enzyme, which copies the viral RNA into DNA and is essential for its replication. The first breakthrough ...
[2] [3] [4] It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare: [5] abacavir sulfate (ABC) lamivudine (3TC) zidovudine (AZT or ZDV) It is indicated in the treatment of AIDS/HIV-1. [2]
The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. [5] The first nucleoside reverse-transcriptase inhibitor with in vitro anti-HIV activity was zidovudine. [6] Since zidovudine was approved in 1987, six nucleosides and one nucleotide reverse-transcriptase inhibitor (NRTI) have been approved by ...
HIV-1 RT does not have proof-reading activity. This, combined with selective pressure from the drug, leads to mutations in reverse transcriptase that make the virus less susceptible to NRTIs and NNRTIs. Aspartate residues 110, 185, and 186 in the reverse transcriptase polymerase domain are important in the binding and incorporation of nucleotides.
Reverse transcriptase (RT) is an enzyme that controls the replication of the genetic material of HIV and other retroviruses. [1] The enzyme has two enzymatic functions. Firstly it acts as a polymerase where it transcribes the single-stranded RNA genome into single-stranded DNA and subsequently builds a complementary strand o
nucleoside reverse transcriptase inhibitor: Nevirapine: non-nucleoside reverse transcriptase inhibitor: Zidovudine: nucleoside reverse transcriptase inhibitor: Clinical data; Trade names: Duovir-N, Zidovex-LN, others [1] ATC code
The Stanford HIV RT and Protease Sequence Database (also called the “HIV Drug Resistance Database”) was formed in 1998 with HIV reverse transcriptase and protease sequences from persons with well-characterized antiretroviral treatment histories, and is publicly available to query resistance mutations and genotype-treatment, genotype ...
Ad
related to: zdv reverse transcriptaseapexbt.com has been visited by 10K+ users in the past month