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The end-bulbs of Krause were thought to be thermoreceptors, sensing cold temperatures, but in early research their function remained unknown. [3] Recently optogenetic studies revealed their role in sexual stimulation and mating behavior in mice:
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The end-bulb of Krause or bulboid corpuscle detects temperatures above body temperature. Ruffini's end organ detects temperatures below body temperature. TRPV1 is a heat-activated channel that acts as a small heat detecting thermometer in the membrane which begins the polarization of the neural fiber when exposed to changes in temperature.
Johann Friedrich Wilhelm Krause (12 July 1833 – 4 February 1910) was a German anatomist born in Hanover. He was the son of anatomist Karl Friedrich Theodor Krause (1797-1868). Krause studied at Göttingen , where he became member of the Burschenschaft Hannovera (fraternity).
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Function block: Each function on an FFBD should be separate and be represented by single box (solid line). Each function needs to stand for definite, finite, discrete action to be accomplished by system elements. Function numbering: Each level should have a consistent number scheme and provide information concerning function origin. These ...
This spindle-shaped receptor is sensitive to skin stretch, and contributes to the kinesthetic sense of and control of finger position and movement. [3] They are at the highest density around the fingernails where they act in monitoring slippage of objects along the surface of the skin, allowing modulation of grip on an object.