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The broad range of ligands that bind to the ER can create a spectrum of ER complexes that are fully estrogenic or antiestrogenic at a specific target site. [ 3 ] [ 4 ] [ 22 ] The main result of a ligand-binding to ER is a structural rearrangement of the ligand- binding pocket , primarily in the AF-2 of the C-terminal region.
There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively).Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. [3]
SlideShare is an American hosting service, now owned by Scribd, for professional content including presentations, infographics, documents, and videos. Users can upload files privately or publicly in PowerPoint, Word, or PDF format. Content can then be viewed on the site itself, on mobile devices or embedded on other sites.
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The enhanced entity–relationship (EER) model (or extended entity–relationship model) in computer science is a high-level or conceptual data model incorporating extensions to the original entity–relationship (ER) model, used in the design of databases.
The ER is made up of flattened sacs and branching tubules that are thought to interconnect, so that the ER membrane forms a continuous sheet enclosing a single internal space. This highly convoluted space is called the ER lumen and is also referred to as the ER cisternal space.
After translation, proteins within the ER make sure that the protein is folded correctly. If after a first attempt the folding is unsuccessful, a second folding is attempted. If this fails too the protein is exported to the cytosol and labelled for destruction. Aside from the folding, there is also a sugar chain added to the protein.
The term "PowerPoint karaoke" is also sometimes derisively used to refer to presenters who face the screen where their PowerPoint slides are being projected and proceed to read them, boring and effectively ignoring their audience. Spanish conceptual artist Rubén Grilo used "PowerPoint Karaoke" as a title for a show at MARCO in June 2011.