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Most MS findings take place inside the white matter, and lesions appear mainly in a periventricular distribution (clustered around the ventricles of the brain). Apart from white matter demyelination, the cortex and deep gray matter (GM) nuclei can be affected, together with diffuse injury of the NAWM. [ 13 ]
Multiple sclerosis (MS) is an autoimmune disease resulting in damage to the insulating covers of nerve cells in the brain and spinal cord. [3] As a demyelinating disease , MS disrupts the nervous system's ability to transmit signals , resulting in a range of signs and symptoms , including physical, mental , and sometimes psychiatric problems.
Abundant extracellular myelin in the meninges of patients with multiple sclerosis has been found [118] Brain tissues with MRI-hidden problems are usually named Normal Appearing. Exploring the normal-appearing corpus callosum has been found a possible primary hypoperfusion, [119] according with other findings in this same direction.
Nearly 2.3 million people are estimated to be living with multiple sclerosis around the world, ... particularly when the disease progresses. I have learned through my personal journey that you own ...
Each attack on the nervous system leaves behind lesions that, together, tell the story of MS in a person's body. One isolated symptom doesn't tell the story of MS. It takes multiple lesions to ...
Main symptoms of multiple sclerosis Symptoms and findings in multiple sclerosis. Multiple sclerosis can cause a variety of symptoms varying significantly in severity and progression among individuals: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in speech or swallowing (), visual ...
“Estrogen, particularly estradiol, the strongest form, plays a critical role in the brain’s health and functionality, earning it the title of the ‘master regulator’ of women’s brain health.
In multiple sclerosis, inflammatory cytokines disrupt the blood–brain barrier and allow for the migration of peripheral immune cells into the central nervous system. When they have migrated into the central nervous system , B cells and plasma cells produce antibodies against the myelin sheath that insulates neurons, degrading the myelin and ...
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