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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
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Dogs with idiopathic epilepsy experience their first seizure between the ages of one and three. However, the age at diagnosis is only one factor in diagnosing canine epilepsy, as one study found cause for seizures in one-third of dogs between the ages of one and three, indicating secondary or reactive rather than primary epilepsy.
Canine epileptoid cramping syndrome (CECS), previously known as Spike's disease, is a hereditary dog disease initially found in Border Terriers and has since been documented in many other dog breeds including Labrador Retrievers and Chihuahuas, with similarities to canine epilepsy. Its cause is unknown. [1]
Its effect is similar to but stronger than picrotoxin, a GABA-A receptor antagonist widely used in research. As one of the most hazardous pesticides, it is 100 times more toxic than potassium cyanide. TETS binds to neuronal GABA gated chloride channels, often causing status epilepticus. No antidote is known.
No seizures were seen within 16 hours of acepromazine administration in the 36 dogs that received the drug, and the seizures abated for 1.5 to 8 hours (n=6) or did not recur (n=2) in eight of 10 dogs that were actively seizing. Excitement-induced seizures were reduced for 2 months in one dog. [17]
Rage syndrome is a rare seizure disorder in dogs, characterized by explosive aggression. [1] [2] [3]It is frequently confused with idiopathic aggression, a term for aggression with no identifiable cause.
While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil. [ 1 ] [ 2 ] This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further.
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