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Both forms of gastrin are found in the gastric antrum and duodenum: Gastrins stimulate the secretion of gastric acid, pepsinogen, intrinsic factor, and secretin; stimulate intestinal mucosal growth; increase gastric and intestinal motility Big gastrin: 3839: 34: Secretin-glucagon family: Secretin: 3056: 27: Duodenum and jejunum
Gastric acid or stomach acid is the acidic component – hydrochloric acid of gastric juice, produced by parietal cells in the gastric glands of the stomach lining. In humans, the pH is between one and three, much lower than most other animals, but is very similar to that of carrion eating carnivores , needing protection from ingesting pathogens .
A canaliculus is an adaptation found on gastric parietal cells. It is a deep infolding, or little channel, which serves to increase the surface area, e.g. for secretion. The parietal cell membrane is dynamic; the numbers of canaliculi rise and fall according to secretory n
Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three:
Effects on endocrine secretion Effects on exocrine secretion Effects on motility Other effects Stimulus for release; Gastrin: G Cells in stomach ECL cells; parietal cells None Increases acid secretion, increases mucus growth Stimulates gastric contraction None Peptides and amino acids in lumen; gastrin releasing peptide and ACh in nervous reflexes
Hyperchlorhydria, sometimes called chlorhydria, sour stomach or acid stomach, [1] [2] refers to the state in the stomach where gastric acid levels are higher than the reference range. The combining forms of the name ( chlor- + hydr- ), referring to chlorine and hydrogen , are the same as those in the name of hydrochloric acid , which is the ...
The gastric glands open into gastric pits in the mucosa. The gastric mucosa is covered in surface mucous cells that produce the mucus necessary to protect the stomach's epithelial lining from gastric acid secreted by parietal cells in the glands, and from pepsin, a secreted digestive enzyme. Surface mucous cells follow the indentations and ...
Efferent fibers of the vagus nerve then release acetylcholine onto gastric parietal cell M 3 receptors, causing insertion of hydrogen potassium ATPase vesicles into the apical plasma membrane. The end result is increased secretion of gastric acid with eventual ulceration of the gastric mucosa.