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The concept of replacing hydrogen with deuterium is an example of bioisosterism, whereby similar biological effects to a known drug are produced in an analog designed to confer superior properties. [5]
The exchange reaction can be followed using a variety of methods (see Detection). Since this exchange is an equilibrium reaction, the molar amount of deuterium should be high compared to the exchangeable protons of the substrate. For instance, deuterium is added to a protein in H 2 O by diluting the H 2 O solution with D 2 O (e.g. tenfold ...
Deuterated acetone is prepared by the reaction of acetone with heavy water, 2 H 2 O or D 2 O, in the presence of a base. In this case, the base used is deuterated lithium hydroxide : [ 1 ] In order to fully deuterate the acetone, the process is repeated several times, distilling off the acetone from the heavy water, and re-running the reaction ...
The Trends series was established in 1976 with Trends in Biochemical Sciences, rapidly followed by Trends in Neurosciences, Trends in Pharmacological Sciences, and Immunology Today. Immunology Today, Parasitology Today, and Molecular Medicine Today changed their names to Trends in... in 2001. Drug Discovery Today was spun off as an independent ...
Deuterated benzene will undergo all the same reactions its normal analogue will, just a little more slowly due to the kinetic isotope effect. For example, deuterated benzene could be used in the synthesis of deuterated benzoic acid , if desired:
Desulfovibrio vulgaris is the best-studied sulfate-reducing microorganism species; the bar in the upper right is 0.5 micrometre long.. Sulfate-reducing microorganisms (SRM) or sulfate-reducing prokaryotes (SRP) are a group composed of sulfate-reducing bacteria (SRB) and sulfate-reducing archaea (SRA), both of which can perform anaerobic respiration utilizing sulfate (SO 2−
Future Microbiology is a peer-reviewed medical journal that was established in 2006 and is published by Future Medicine. The editors-in-chief are Richard A. Calderone ( Georgetown University ) and B. Brett Finlay ( University of British Columbia ).
Recent data suggest that iron-chelating molecules with similar properties to siderophores, were produced by marine bacteria under phosphate limiting growth condition. In nature phosphate binds to different type of iron minerals, and therefore it was hypothesized that bacteria can use siderophore-like molecules to dissolve such complex in order ...