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The Henderson–Hasselbalch equation relates the pH of a solution containing a mixture of the two components to the acid dissociation constant, K a of the acid, and the concentrations of the species in solution. [6] Simulated titration of an acidified solution of a weak acid (pK a = 4.7) with alkali
The isohydric principle is the phenomenon whereby multiple acid/base pairs in solution will be in equilibrium with one another, tied together by their common reagent: the hydrogen ion and hence, the pH of solution. That is, when several buffers are present together in the same solution, they are all exposed to the same hydrogen ion activity.
Karl Albert Hasselbalch (Danish pronunciation: [ˈkʰɑˀl ˈælˀpɐt ˈhæsl̩ˌpælˀk]; 1 November 1874 – 19 September 1962) was a Danish physician and chemist known for his work on the Henderson–Hasselbalch equation.
The ratio of acid, AH and conjugate base, A −, concentrations varies as the difference between the pH and the pK a varies, in accordance with the Henderson-Hasselbalch equation. The pH of a solution of a monoprotic weak acid can be expressed in terms of the extent of dissociation. After rearranging the expression defining the acid ...
As calculated by the Henderson–Hasselbalch equation, in order to maintain a normal pH of 7.4 in the blood (whereby the pK a of carbonic acid is 6.1 at physiological temperature), a 20:1 ratio of bicarbonate to carbonic acid must constantly be maintained; this homeostasis is mainly mediated by pH sensors in the medulla oblongata of the brain ...
He documented the success of six competitive runners who followed in one form or another an LSD training regime, sometimes combining a few more strenuous workouts with the regular LSD running with weekly mileages ranging from 50–60 miles (80–100 km) to 120–150 miles (190–240 km) per week, with marathon personal bests between 2:14 and 2: ...
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Lawrence Henderson was born in Lynn, Massachusetts the son of a business man Joseph Henderson and his wife. He entered Harvard at the age of 16 in 1894. His father was a ship chandler whose principal business was located in nearby Salem, but who also conducted business in Saint Pierre and Miquelon, a French Overseas collectivity off the coast of Canada.