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[212] [213] Controlled trials spanning two years have demonstrated continuous treatment effectiveness and safety. [213] [214] One review highlighted a nine-month randomized controlled trial of amphetamine in children that found an average increase of 4.5 IQ points and continued improvements in attention, disruptive behaviors, and hyperactivity ...
ATT-377 – Combination treatment of Methylphenidate ER, cyproheptadine [1] TRN-110 [extended-release] – undefined mechanism / extended-release form of an undisclosed drug [ 2 ] Phase 3 clinical trials
A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different pharmacotherapies used in randomized controlled trials (RCTs) for amphetamine and methamphetamine addiction; [147] it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration. [147]
Two common trade brands for ADHD medication, Adderall and Concerta are made from different drug formulas. Adderall is made from amphetamine mixed salts and Concerta is made from methylphenidate.
Long-term amphetamine exposure at sufficiently high doses in some animal species is known to produce abnormal dopamine system development or nerve damage, [27] [28] but, in humans with ADHD, long-term use of pharmaceutical amphetamines at therapeutic doses appears to improve brain development and nerve growth.
Amphetamines and methylphenidate are classified by the Drug Enforcement Administration as Schedule II controlled substances, the same designation given to cocaine, OxyContin and fentanyl.
[95] [96] [97] A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different pharmacotherapies used in randomized controlled trials (RCTs) for amphetamine and methamphetamine addiction; [96] it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration. [96]
A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different pharmacotherapies used in randomized controlled trials (RCTs) for amphetamine and methamphetamine addiction; [158] it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration. [158]
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