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Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [ 1 ] They are named after their chemical structure , which contains three rings of atoms .
Toggle Norepinephrine–dopamine reuptake inhibitors (NDRIs) subsection. 8.1 Off-label only. ... Tricyclic antidepressants include: Amitriptyline (Elavil, Endep)
Actions of imipramine-like tricyclic antidepressants have complex, secondary adaptions to their initial and sustained actions as inhibitors of norepinephrine transport and variable blockade of serotonin transport. Norepinephrine interacts with postsynaptic α and β adrenergic receptor subtypes and presynaptic α 2 autoreceptors.
Tricyclic antidepressants (TCAs) Tetracyclic antidepressants (TeCAs) Monoamine oxidase inhibitors (MAOIs) ... Serotonin–norepinephrine reuptake inhibitors, or SNRIs, are a common type of ...
Tricyclic antidepressants (TCAs) Dopamine reuptake inhibitors (DRIs) and norepinephrine–dopamine reuptake inhibitors (NDRIs) ... Norepinephrine helps regulate your sleep-wake cycle, stimulates ...
The majority of the tricyclic antidepressants (TCAs) act primarily as serotonin–norepinephrine reuptake inhibitors (SNRIs) by blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET), respectively, which results in an elevation of the synaptic concentrations of these neurotransmitters, and therefore an enhancement of ...
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
Imipramine is a tertiary TCA, and is a potent inhibitor of serotonin reuptake, and to a greater extent than secondary amine TCAs such as nortriptyline and despiramine. [45] Norepinephrine: strong reuptake inhibition. Desipramine has more affinity to norepinephrine transporter than imipramine. Dopamine: imipramine blocks D 2 receptors. [46]