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In pharmaceutical chemistry, numerous methods exist to help solubilize poorly water-soluble drugs for use in treatment. These methods include cosolvency, hydrotropism, complexation, ionization, and using surface active agents.
After each individual layer is synthesized, aquasomes self-assemble into triple-layered particles. The tri-layer structure enables aquasomes to deliver and release poorly soluble drugs in a controlled manner. Delivery of these poorly soluble drugs within aquasomes increases their solubility, bioavailability, and stability.
Ordered mesoporous silica (e.g. SBA-15, [21] TUD-1, [22] HMM-33, [1] and FSM-16 [23]) also show potential to boost the in vitro and in vivo dissolution of poorly water-soluble drugs. Many drug-candidates coming from drug discovery suffer from a poor water solubility.
One of the issues faced by drug delivery is the solubility of the drug in the body; around 40% of newly detected chemicals found in drug discovery are poorly soluble in water. [28] This low solubility affects the bioavailability of the drug, meaning the rate at which the drug reaches the circulatory system and thus the target site.
MMCs have been shown to successfully increase the apparent solubility of several poorly soluble model drugs, including Ibuprofen, [6] [7] [8] itraconacole, [3] tolfenamic, rimonabant, [9] celecoxib, cinnarizine and griseofulvin. [10] They do so by suppressing crystallization of the drug substance incorporated into the pores of the materials.
The drugs are classified in BCS on the basis of solubility and permeability. Solubility class boundaries are based on the highest dose strength of an immediate release product. A drug is considered highly soluble when the highest dose strength is soluble in 250 ml or less of aqueous media over the pH range of 1 to 6.8.
Additionally, improved bioavailability, protection of sensitive drug molecules from the outer environment (e.g. water, light), and even controlled release characteristics were claimed by the incorporation of poorly water-soluble drugs in the solid lipid matrix. Moreover, SLNs can carry both lipophilic and hydrophilic drugs, and are more ...
Hot melt extrusion is utilized in pharmaceutical solid oral dose processing to enable delivery of drugs with poor solubility and bioavailability. Hot melt extrusion has been shown to molecularly disperse poorly soluble drugs in a polymer carrier increasing dissolution rates and bioavailability.