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Pulmonary surfactant is a surface-active complex ... a basic health system ... with the adaptive immune response. Surfactant degradation or inactivation may ...
Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin. [5] In humans, SP-D is encoded by the SFTPD gene [ 6 ] [ 7 ] and is part of the innate immune system .
Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion ...
The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. Alveolar sac region of the lung - TEM. SP-A1 is a member of a subfamily of C-type lectins called collectins. Together with SP-A2, they are the most abundant proteins of pulmonary surfactant.
Pulmonary surfactant protein D (SP-D), has an important role in acting as a lung host defence protein. SP-D has a significant roles in immune and inflammatory regulation of the lung as it regulates of the level of surfactant in the lungs by a process named surfactant homeostasis. [2]
Lung surfactant (LS) is a surface-active material produced by most air-breathing animals for the purpose of reducing the surface tension of the water layer where gas exchange occurs in the lungs, given that the movements due to inhalation and exhalation may cause damage if there is not enough energy to sustain alveolar structural integrity.
Furthermore, surfactants also contains some innate immune components to defend against pulmonary infections. Surfactant is classified into two types of proteins, hydrophilic proteins that are responsible for innate immune system, and hydrophobic proteins that carry out physical functions of pulmonary surfactant. [3]
The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. [7] Alveolar sac region of the lung - TEM. SP-A2 is a member of a subfamily of C-type lectins called collectins. Together with (surfactant protein A1 ) SP-A1, they are the most abundant proteins of pulmonary surfactant.