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α/β proteins are a class of structural domains in which the secondary structure is composed of alternating α-helices and β-strands along the backbone. The β-strands are therefore mostly parallel. [4] Common examples include the flavodoxin fold, the TIM barrel and leucine-rich-repeat (LRR) proteins such as ribonuclease inhibitor.
Structural Classification of Proteins database (SCOP) [4] Both classification schemes are based on a hierarchy of fold types. At the top level are all alpha proteins (domains consisting of alpha helices), all beta proteins (domains consisting of beta sheets), and mixed alpha helix/beta sheet proteins.
Some protein dynamics [8] and conformational changes of the protein structure may also be conserved, as is seen in the serpin superfamily. [9] Consequently, protein tertiary structure can be used to detect homology between proteins even when no evidence of relatedness remains in their sequences.
The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins.
A successful search yields the class, folds, superfamilies, families, and individual proteins matching the query. Domain Assignments The database has domain assignments, alignments, and architectures for completely sequence eukaryotic and prokaryotic organisms, plus sequence collections.
Protein dynamics and conformational changes allow proteins to function as nanoscale biological machines within cells, often in the form of multi-protein complexes. [14] Examples include motor proteins, such as myosin, which is responsible for muscle contraction, kinesin, which moves cargo inside cells away from the nucleus along microtubules ...
Protein subfamily is a level of protein classification, based on their close evolutionary relationship. It is below the larger levels of protein superfamily and protein family. [1] Proteins typically share greater sequence and function similarities with other subfamily members than they do with members of their wider family.
A protein is a complex, high molecular weight organic compound that consists of amino acids joined by peptide bonds. Organize articles about proteins according to a standard protein ontology . Contents