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19-Norandrosterone, also known as 5α-estran-3α-ol-17-one, is a metabolite of nandrolone (19-nortestosterone) and bolandione (19-norandrostenedione) that is formed by 5α-reductase. It is on the list of substances prohibited by the World Anti-Doping Agency since it is a detectable metabolite of nandrolone, an anabolic-androgenic steroid (AAS). [1]
Activation of remdesivir into its active triphosphate metabolite [33] Remdesivir is a protide ( prodrug of nucleotide) able to diffuse into cells, where it is converted to GS-441524 monophosphate via the actions of esterases ( CES1 and CTSA ) and a phosphoamidase ( HINT1 ); this in turn is further phosphorylated to its active metabolite ...
3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.In the brain, it is the principal norepinephrine metabolite. It is released into the blood and cerebrospinal fluid, [1] and a blood sample of it may therefore be an indication of recent sympathetic nervous system activity.
b) The same principle applies to metabolites that are also prone to damage by enzymatic errors or spontaneous chemical reactions. Metabolite repair systems can either repair the damage or pre-empt it; directed overflow is a special case of damage pre-emption. Metabolite damage-control systems fall into three different categories:
In biochemistry, a metabolite is an intermediate or end product of metabolism. [1] The term is usually used for small molecules.Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and ...
Coley's toxins (also called Coley's toxin, [1] Coley's vaccine, [2] Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture containing toxins filtered from killed bacteria of species Streptococcus pyogenes and Serratia marcescens, named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment ...
Metabolome databases can be distinguished from metabolite databases in that metabolite databases contain lightly annotated or synoptic metabolite data from multiple organisms while metabolome databases contain richly detailed and heavily referenced chemical, pathway, spectral and metabolite concentration data for specific organisms.
Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions. It results from the reaction of isoxazole ring opening, which occurs in vivo . Teriflunomide then can interconvert between the E and Z enolic forms (and the corresponding keto-amide), the Z -enol being the most stable and therefore ...