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Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow.It increases in states of low bone density, such as osteoporosis, [1] [2] anorexia nervosa/caloric restriction, [3] [4] skeletal unweighting such as that which occurs in space travel, [5] [6] and anti-diabetes therapies. [7]
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. [2] In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). [3] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells.
Histopathology of a pulmonary artery with fat embolism (seen as multiple empty globular spaces on this H&E stain since its processing dissolves fat). There is a bone marrow fragment in the middle, and multiple single hematopoietic cells in the blood, being evidence of fracture as the source of the embolism.
Marrow fat, also known as marrow adipose tissue (MAT), is a poorly understood adipose depot that resides in the bone and is interspersed with hematopoietic cells as well as bony elements. The adipocytes in this depot are derived from mesenchymal stem cells (MSC) which can give rise to fat cells, bone cells as well as other cell types. The fact ...
Body composition refers to the percentages body fat, bone, and lean tissue mass (basically, the muscle, organs, water, and other types of tissue) in your body.
Beef bone marrow is also a main ingredient in the Italian dish ossobuco (braised veal shanks); the shanks are cross-cut and served bone-in, with the marrow still inside the bone. Beef marrow bones are often included in the French pot-au-feu broth, the cooked marrow being traditionally eaten on toasted bread with sprinkled coarse sea salt. [6]
Marrow adipocytes are unilocular like white fat cells. The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in the setting of obesity. [4]
Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. [2] Diet restrictions do not help prevent the buildup of lipids in the tissues because the cells in the tissues synthesize lipids from any precursor readily available (such as amino acids or carbohydrates). [1]