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  2. Embolic and thrombotic events after COVID-19 vaccination

    en.wikipedia.org/wiki/Embolic_and_thrombotic...

    The rare simultaneous occurrence of thrombocytopenia (low blood platelets) with blood clots after vaccination raised the original concern about this condition. [citation needed] In many cases where acute thrombosis and thrombocytopenia have been found together after COVID‑19 vaccination, an antibody against platelet factor 4 has been ...

  3. Pfizer–BioNTech COVID-19 vaccine - Wikipedia

    en.wikipedia.org/wiki/Pfizer–BioNTech_COVID-19...

    A test-negative [note 1] case-control study published in August 2021, found that two doses of the BNT162b2 (Pfizer) vaccine had 93.7% effectiveness against symptomatic disease caused by the alpha (B.1.1.7) variant and 88.0% effectiveness against symptomatic disease caused by the delta (B.1.617.2) variant. [87]

  4. Teens experience side effects after Pfizer's shot slightly ...

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  5. COVID-19 vaccine clinical research - Wikipedia

    en.wikipedia.org/wiki/COVID-19_vaccine_clinical...

    In the UK, 15,121 health care workers from 104 hospitals who had tested negative for antibodies prior to the study, were followed by RT-PCR tests twice a week from 7 December 2020 to 5 February 2021, a study compared the positive results for the 90.7% vaccinated share of their cohort with the 9.3% unvaccinated share, and found that the Pfizer ...

  6. Shoulder injury related to vaccine administration - Wikipedia

    en.wikipedia.org/wiki/Shoulder_injury_related_to...

    In the United States, SIRVA was added to the list of compensable injuries on the Vaccine Injury Table used by the National Vaccine Injury Compensation Program in 2017. [6] [7] This inclusion allowed persons claiming an injury to seek compensation from a government fund set up under the program, while immunizing vaccine manufacturers and administrators from legal liability.

  7. Reactogenicity - Wikipedia

    en.wikipedia.org/wiki/Reactogenicity

    Mechanisms underlying the cause of reactogenicity symptoms. In clinical trials, reactogenicity is the capacity of a vaccine to produce common, "expected" adverse reactions, especially excessive immunological responses and associated signs and symptoms, including fever and sore arm at the injection site.

  8. ALC-0315 - Wikipedia

    en.wikipedia.org/wiki/ALC-0315

    The preparation of ALC-0315 was first described in a patent application to lipid nanoparticles by Acuitas Therapeutics in 2017. [6]: 137 The final step is a reductive amination reaction in which 4-aminobutanol is condensed with a lipid aldehyde, using sodium triacetoxyborohydride as the reducing agent to convert the intermediate imines to the amine of the product.

  9. FDA approves Pfizer's first gene therapy for rare inherited ...

    www.aol.com/news/fda-approves-pfizer-first-gene...

    The Food and Drug Administration on Friday approved Pfizer’s treatment for a rare genetic bleeding disorder, making it the company’s first-ever gene therapy to win clearance in the U.S.