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The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The neurotransmitter serotonin (illustration) has various receptors. A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.
5-HT2C receptor agonists are a class of drugs that activate 5-HT 2C receptors. They have been investigated for the treatment of a number of conditions including obesity, psychiatric disorders, sexual dysfunction and urinary incontinence. [1][2][3][4][5] The 5-HT 2C receptors are one of three subtypes that belong to the serotonin 5-HT 2 receptor ...
Serotonin can also be synthesized, albeit at very low levels, in the bone cells. It mediates its actions on bone cells using three different receptors. Through 5-HT 1B receptors, it negatively regulates bone mass, while it does so positively through 5-HT 2B receptors and 5-HT 2C receptors. There is very delicate balance between physiological ...
Contents. 5-HT 2C receptor. The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G q /G 11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for ...
These effects are the result of activation of 5-HT 1A receptors within the rostral ventrolateral medulla. [10] The sympatholytic antihypertensive drug urapidil is an α 1-adrenergic receptor antagonist and 5-HT 1A receptor agonist, and it has been demonstrated that the latter property contributes to its overall therapeutic effects.
Wikidata. View/Edit Human. View/Edit Mouse. The 5-HT2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [ 4 ] The 5-HT 2A receptor is a cell surface receptor, [ 5 ] but has several intracellular locations. [ 6 ] Like all 5-HT 2 receptors, the 5-HT 2A receptor ...
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. [1][2][3] This ion channel is cation -selective and mediates neuronal depolarization ...
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